Resurfacing work on the A40 near the Golden Valley is due to start on Monday.
The work to get rid of potholes was due to get under way last week but it will now start on Monday and continue for three days.
The road between the M5 and Cheltenham’s Arle Court roundabout will be shut while the work is done between the hours of 7pm and 6am.
A diversion will be put in place. The resurfacing is dependent on good weather.
Councillor Vernon Smith, county council cabinet member for highways and flood, said: “This is important road improvement work and it will significantly improve a well-used road.”