GLOUCESTER centre Billy Twelvetrees will make his England debut in Saturday's Calcutta Cup clash with Scotland at Twickenham.
The 24-year-old who made the switch from Leicester to Gloucester in the summer joins teammate Ben Morgan in the starting lineup for the opening Six Nations encounter.
Twelvetrees replaced injured Leicester centre Manu Tuilagi as Brad Barrit's midfield partner in a side that shows two changes from the one that recorded a historic victory over New Zealand in the Autumn Internationals.
Harlequins prop Joe Marler replaces injured London Irish loosehead Alex Corbisiero in the starting XV, while Dylan Hartley, Toby Flood and David Strettle come on to the replacements' bench for David Paice, Freddie Burns and Jonathan Joseph respectively.
England Head Coach Stuart Lancaster said: "We are happy to stick with the team that did so well against New Zealand, especially in light of the fact that they have all been in good form for their clubs since then.
"There were some very tight calls, with some experienced players coming back into contention, and I am sure the bench will have a significant impact on the game.
"We can't wait to get back to Twickenham and hopefully experience the same atmosphere as the autumn when the crowd was superb. It means a lot to the players to have such support in the ground and watching on television."
Gloucester captain Jim Hamilton starts for Scotland as does former Kingsholm flanker Alasdair Strokosch, who now plays for Perpignan.
England (v Scotland, Saturday, 4pm, Twickenham Stadium)
15. Alex Goode (Saracens, 6 caps)
14. Chris Ashton (Saracens, 29 caps)
13. Brad Barritt (Saracens, 11 caps)
12. Billy Twelvetrees (Gloucester Rugby, uncapped)
11. Mike Brown (Harlequins, 11 caps)
10. Owen Farrell (Saracens, 12 caps)
9. Ben Youngs (Leicester Tigers, 28 caps)
1. Joe Marler (Harlequins, 5 caps)
2. Tom Youngs (Leicester Tigers, 4 caps)
3. Dan Cole (Leicester Tigers, 35 caps)
4. Joe Launchbury (London Wasps, 4 caps)
5. Geoff Parling (Leicester Tigers, 12 caps)
6. Tom Wood (Northampton Saints, 13 caps)
7. Chris Robshaw (Harlequins, capt, 12 caps)
8. Ben Morgan (Gloucester Rugby, 9 caps)
16. Dylan Hartley (Northampton Saints, 42 caps)
17. David Wilson (Bath Rugby, 22 caps)
18. Mako Vunipola (Saracens, 4 caps)
19. Courtney Lawes (Northampton Saints, 15 caps)
20. James Haskell (London Wasps, 45 caps)
21. Danny Care (Harlequins, 37 caps)
22. Toby Flood (Leicester Tigers, 53 caps)
23. David Strettle (Saracens, 12 caps)