Two people in England have developed tuberculosis after contact with a domestic cat infected with Mycobacterium bovis (M. bovis), Public Health England (PHE) and the Animal Health and Veterinary Laboratories Agency (AHVLA) have announced. M. bovis is the bacterium that causes tuberculosis (TB) in cattle (bovine TB) and in other species.
Nine cases of M. bovis infection in domestic cats in Berkshire and Hampshire were investigated by AHVLA and PHE during 2013. PHE offered TB screening to 39 people identified as having had contact with the infected cats as a precautionary measure. 24 contacts accepted screening. Following further investigations, a total of two cases of active TB and two cases of latent TB were identified. Latent TB means they had been exposed to TB at some point but they did not have active disease. Both cases of active TB disease have confirmed infection with M. bovis and are responding to treatment.
There have been no further cases of TB in cats reported in Berkshire or Hampshire since March 2013. PHE has assessed the risk of transmission of M. bovis from cats to humans as being very low.
Dr Dilys Morgan, head of gastrointestinal, emerging and zoonotic diseases department at PHE, said: “It’s important to remember that this was a very unusual cluster of TB in domestic cats. M. bovis is still uncommon in cats - it mainly affects livestock animals. These are the first documented cases of cat-to-human transmission, and so although PHE has assessed the risk of people catching this infection from infected cats as being very low, we are recommending that household and close contacts of cats with confirmed M. bovis infection should be assessed and receive public health advice.”
The findings of the animal health aspects of this investigation are published in The Veterinary Record today.
Molecular analysis at AHVLA showed that M. bovis isolated from the infected cats and the human cases with active TB infection were indistinguishable, which indicates transmission of the bacterium from an infected cat. In the other cases of latent TB infection, it is not possible to confirm whether these were caused by M. bovis or the source of their exposure.
Transmission of M. bovis from infected animals to humans can occur by inhaling or ingesting bacteria shed by the animal or through contamination of unprotected cuts in the skin while handling infected animals or their carcasses.
Professor Noel Smith, Head of the Bovine TB Genotyping Group at AHVLA, said: “Testing of nearby herds revealed a small number of infected cattle with the same strain of M. bovis as the cats. However, direct contact of the cats with these cattle was unlikely considering their roaming ranges. The most likely source of infection is infected wildlife, but cat-to-cat transmission cannot be ruled out.”
Cattle herds with confirmed cases of bovine TB in the area have all been placed under movement restrictions to prevent the spread of disease.
Local human and animal health professionals are remaining vigilant for the occurrence of any further cases of disease caused by M. bovis in humans, cats or any other pet and livestock animal species.
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