Entrepreneurs in Gloucester are among the most active in the UK.
Innovation is a driver of long-term economic growth and Gloucester has proven to be up there with th best.
The city is granted 8.9 patents per 100,000 residents, the sixth best in the country.
Above it is only Cambridge, Swindon, Edinburgh, Aberdeen and Aldershot.
And inventors in Gloucester have made it the creative capital of the South West, beating the likes of Bristol.
Annette John, general manager at Prima Dental in Quedgeley, said being in the city has benefited the company.
The team at Waterwells Business Park has transformed it into a global name in the design and manufacture of precision dental products.
She said: “Gloucester is a good place to do business and has helped us expand and grow into a world leader in our sector.
“We benefit from the strong communication networks, a diverse and skilled regional workforce and the strong, supportive business hub.”
Fellow entrepreneur Bob Griffin, who founded Tomcat Trikes in Hucclecote, said local links were important to his firm.
His designs, which help control the speed and braking of the tricycles, have helped hundreds of children with special needs to learn how to cycle.
He said: “When you are changing things, it is easier to just jump in the car and go and see someone about the changes. That is immensely invaluable.”
Bottom of the table is Sunderland, followed by Blackpool and Wigan.