The A40 Golden Valley will be closed overnight for highways teams to fill in dangerous potholes.
A section of the road from the M5 entrance to the Arle Court roundabout is notoriously bad for potholes.
Gloucestershire Highways will be working throughout the night between January 20 and January 24 to repair the holes.
The road will be closed from the M5 sliproad entrance between 8pm and 6am for the repairs to take place. People travelling from Gloucester will still be able to get onto the M5 and diversions will be put in pace for people travelling from Cheltenham.
Road users can expect to see signs on the Golden Valley from next week telling them about the closure.
Cllr Vernon Smith, Gloucestershire County Council cabinet member for highways and flood, said: “This is important road improvement work and it will significantly improve a well-used road.
“We’re extremely grateful for the patience residents have shown us as we carry out improvements like this around the county, and are hopeful that the benefits will far outweigh the inconvenience caused.”
Cllr Simon Wheeler Gloucestershire County councillor for Benhall and Up Hatherley, said: “I very much welcome these road works to the Golden Valley. It will greatly improve both the condition of the road and its safety. I’m sure road users will notice the difference.”